Cranberry extract 25% optimized purity

Cranberry (Vaccinium macrocarpon) is a fruit widely recognized for its role in supporting urinary tract health. Its beneficial properties are primarily attributed to compounds called proanthocyanidins (PACs), which help prevent the adhesion of certain bacteria, such as E. coli, to the urinary tract lining. One of the most effective ways to supplement with cranberry is through standardized extracts, which ensure a reliable concentration of these active compounds.

Cranberry extract standardized to 25% PACs is considered the most clinically effective form for urinary tract support. PACs, especially A-type proanthocyanidins, are known to reduce the risk of recurrent urinary tract infections (UTIs) by interfering with bacterial attachment and biofilm formation. This standardization ensures targeted, evidence-based support for urinary health.

Clinical studies have demonstrated the effectiveness of cranberry extract, particularly when standardized to 25% PACs, for urinary tract health and bacterial defense. For example:

  • In a randomized, double-blind, placebo-controlled study of 160 women with a history of recurrent UTIs, daily supplementation with cranberry extract containing 36 mg PACs significantly reduced the recurrence of UTIs over 24 weeks compared to placebo (Maki et al., 2016).

  • A systematic review and meta-analysis of 24 trials found that cranberry products (with standardized PAC content) significantly reduced the risk of recurrent UTIs, especially in women and children (Jepson et al., 2012).

  • In a clinical study involving elderly patients, cranberry extract with a high PAC content reduced the incidence of bacteriuria and pyuria, suggesting its effectiveness in older populations as well (Caljouw et al., 2014).

Overall, the clinical evidence suggests that cranberry extract standardized to 25% proanthocyanidins is an effective and well-tolerated supplement for maintaining urinary tract health and preventing recurrent infections. As always, individuals should consult a healthcare provider before starting any new supplement regimen.

References:

  1. Maki, K. C., Kaspar, K. L., Khoo, C., Derrig, L. H., Schild, A. L., Gupta, K., & Reeves, M. S. (2016). Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection. American Journal of Clinical Nutrition, 103(6), 1434–1442. https://doi.org/10.3945/ajcn.115.122465

  2. Jepson, R. G., Williams, G., & Craig, J. C. (2012). Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews, (10), CD001321. https://doi.org/10.1002/14651858.CD001321.pub5

  3. Caljouw, M. A., van den Hout, W. B., Putter, H., Achterberg, W. P., & Gussekloo, J. (2014). Effectiveness of cranberry capsules to prevent urinary tract infections in vulnerable older persons: a double-blind randomized placebo-controlled trial in long-term care facilities. BMJ, 349, g5222. https://doi.org/10.1136/bmj.g5222