L-Leucine 99% ultra high purity

L-Leucine is one of the nine essential amino acids and is classified as a branched-chain amino acid (BCAA), alongside isoleucine and valine. It plays a critical role in muscle protein synthesis, energy regulation, and recovery. As the most anabolic of the BCAAs, L-leucine activates cellular pathways involved in muscle building, particularly the mTOR (mechanistic target of rapamycin) pathway. One of the most effective ways to supplement with L-leucine is through standardized high-purity forms, which deliver consistent and targeted support for muscle health.

L-Leucine standardized to 99% purity is considered the most effective form of this amino acid. High-purity L-leucine ensures rapid absorption and bioavailability, maximizing its impact on muscle recovery, strength enhancement, and metabolic regulation. It is especially beneficial for athletes, aging adults, and individuals engaged in resistance training or muscle preservation protocols.

Clinical studies have demonstrated the effectiveness of L-leucine supplementation, particularly when administered in purified, high-concentration forms, for enhancing muscle protein synthesis and preventing muscle loss. For example:

  • In a double-blind randomized study, elderly participants who consumed a leucine-enriched protein supplement showed significantly increased muscle protein synthesis and lean body mass compared to those receiving standard protein (Verhoeven et al., 2009).
  • A randomized clinical trial showed that supplementation with L-leucine (2.5–3 g per meal) enhanced postprandial muscle protein synthesis in older adults, helping counteract age-related sarcopenia (Katsanos et al., 2006).
  • In a study on resistance-trained males, L-leucine supplementation post-exercise led to significantly improved strength recovery and reduced markers of muscle damage, such as creatine kinase (Ispoglou et al., 2011).

Overall, the clinical evidence suggests that L-leucine at 99% purity is a highly effective and bioavailable way to support muscle growth, recovery, and strength maintenance, particularly in physically active individuals or those facing muscle loss due to aging or catabolic conditions.

References:

  1. Verhoeven, S., Vanschoonbeek, K., Verdijk, L. B., Koopman, R., Wodzig, W. K., Dendale, P., & van Loon, L. J. (2009). Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men. American Journal of Clinical Nutrition, 89(5), 1468–1475. https://doi.org/10.3945/ajcn.2008.26909
  2. Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006). A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. American Journal of Physiology-Endocrinology and Metabolism, 291(2), E381–E387. https://doi.org/10.1152/ajpendo.00488.2005
  3. Ispoglou, T., King, R. F. G. J., Polman, R. C. J., & Zanker, C. (2011). Daily L-leucine supplementation in novice trainees during a 12-week weight training program. International Journal of Sports Physiology and Performance, 6(1), 38–50. https://doi.org/10.1123/ijspp.6.1.38