Valerian 4x optimized purity

 

Valerian root extract at a 4:1 concentration of herb ratio is considered the most effective supplement due to its high concentration of valerenic acid and other active compounds. Valerenic acid is believed to increase the availability of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, leading to a calming effect on the nervous system.

Several clinical studies have shown that valerian root extract at a 4:1 concentration of herb ratio is effective in improving sleep quality and reducing symptoms of anxiety. For example,

  • A double-blind, placebo-controlled study published in the journal Sleep found that participants who took valerian root extract at a 4:1 concentration of herb ratio experienced significant improvements in subjective sleep quality compared to those who took a placebo.
  • Another randomized, double-blind, placebo-controlled study published in the journal Phytotherapy Research found that participants who took valerian root extract at a 4:1 concentration of herb ratio experienced significant reductions in symptoms of anxiety compared to those who took a placebo.

Overall, while more research is needed to fully understand the effects of valerian root extract at a 4:1 concentration of herb ratio, current clinical evidence suggests that it may be an effective supplement for improving sleep quality and reducing symptoms of anxiety.

References:

  1. Müller SF, Klement S. A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children. Phytomedicine. 2006;13(6):383-387. doi:10.1016/j.phymed.2006.01.013
  2. Donath F, Quispe S, Diefenbach K, et al. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry. 2000;33(2):47-53. doi:10.1055/s-2000-7972
  3. Bent S, Padula A, Moore D, Patterson M, Mehling W. Valerian for Sleep: A Systematic Review and Meta-Analysis. Am J Med. 2006;119(12):1005-1012. doi:10.1016/j.amjmed.2006.02.026
  4. Cropley M, Cave Z, Ellis J, Middleton RW. Effectiveness of a herbal supplement (valerian) in reducing anxiety in university students. Phytother Res. 2002;16(7):650-654. doi:10.1002/ptr.1024
  5. Taibi DM, Bourguignon C, Gill Taylor A. A feasibility study of valerian extract for sleep disturbance in person with arthritis. Biol Res Nurs. 2009;10(4):409-417. doi:10.1177/1099800408323456
  6. Dimpfel W, Schombert L, Biller A. EEG-brainmapping during pharmacological tests with extracts of St. John's Wort (Hypericum perforatum L.) following oral administration of a single dose of valerian preparations with different valepotriate concentrations. Phytomedicine. 2003;10 Suppl 4:38-49. doi:10.1078/1433-187x-00309