Vitamin K2 optimized purity

Vitamin K2 is a fat-soluble vitamin that plays a crucial role in calcium metabolism, supporting both bone strength and cardiovascular health. Unlike Vitamin K1, which is primarily involved in blood clotting, Vitamin K2 directs calcium to the bones and teeth while helping prevent calcium accumulation in arteries. Since dietary intake of Vitamin K2 is often limited, supplementation provides an effective way to achieve optimal levels.

Vitamin K2 in the menaquinone-7 (MK-7) form at 55 mcg is a safe and effective daily dose that supports long-term bone and cardiovascular health. MK-7 offers a longer half-life than other forms, allowing for more stable blood levels with once-daily dosing. The 55 mcg strength provides daily maintenance support, while higher-dose clinical studies (180 mcg/day) have demonstrated significant improvements in bone mineral density and arterial elasticity.

Clinical studies have demonstrated the effectiveness of Vitamin K2 (MK-7) supplementation, particularly at clinically studied doses, for bone and cardiovascular health. For example:

  • In a 3-year randomized controlled trial, postmenopausal women taking 180 mcg/day of MK-7 experienced improved bone mineral density and reduced bone loss compared to placebo (Knapen et al., 2013).
  • A double-blind study showed that 180 mcg/day of MK-7 significantly improved arterial elasticity and reduced age-related stiffening in healthy postmenopausal women (Knapen et al., 2015).
  • Observational data from the Rotterdam Study found that higher dietary Vitamin K2 intake was associated with reduced risk of coronary heart disease and vascular calcification (Geleijnse et al., 2004).

Overall, the clinical evidence suggests that Vitamin K2 in the MK-7 form is a safe and effective supplement for supporting bone strength, calcium utilization, and cardiovascular well-being. A daily intake of 55 mcg provides reliable maintenance support, while higher intakes studied in clinical trials further demonstrate its long-term health benefits. As with any supplement, individual responses may vary, and consultation with a healthcare provider is recommended before use.

References:

  1. Knapen, M. H., Drummen, N. E., Smit, E., Vermeer, C., & Theuwissen, E. (2013). Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis International, 24(9), 2499–2507. https://doi.org/10.1007/s00198-013-2325-6
  2. Knapen, M. H., Braam, L. A., Drummen, N. E., Bekers, O., Hoeks, A. P., & Vermeer, C. (2015). Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. Thrombosis and Haemostasis, 113(5), 1135–1144. https://doi.org/10.1160/TH14-08-0675
  3. Geleijnse, J. M., Vermeer, C., Grobbee, D. E., Schurgers, L. J., Knapen, M. H., van der Meer, I. M., & Witteman, J. C. (2004). Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. Journal of Nutrition, 134(11), 3100–3105. https://doi.org/10.1093/jn/134.11.3100